A 27-year-old man was arrested in Bourke about 9am on Wednesday.

He was taken to Bourke Police Station and charged with six counts of supply prohibited drug, and possess prohibited drug.

Shortly after, a second man, aged 27, was arrested at a home in Bourke, and a 34-year-old woman was arrested at a third address in Bourke.

The man was charged with four counts of supply prohibited drug, possess prohibited drug, and possess equipment for administering drug.

The woman was charged with two counts of supply prohibited drug.

The two men were bail refused to appear at Bourke Local Court on Thursday.

The woman was granted conditional bail to appear at Bourke Local Court on September 10.

About 10.35am on Wednesday, officers attached to Central West Police District arrested a 34-year-old man at a home on Leumeah Place in Orange.

He was taken to Orange Police Station where he was charged with supply prohibited drug, and breach of bail.

The man was bail refused to appear before Orange Local Court on Thursday.

In May 2020, detectives attached to Central North Police District established Strike Force Portside to investigate the supply of prohibited drugs in the Bourke area.

Central North Police District Commander, Superintendent Andrew Hurst, said the arrests come after months of dedicated police work focused on disrupting drug-related crime in the Central North Police District.

"This investigation follows inquiries conducted under Strike Force Quarrang which resulted in the arrest of seven people in April this year," Superintendent Hurst said.

"I acknowledge the excellent work performed by the Proactive Crime Team in achieving these results and taking further steps to eliminate the supply of prohibited drugs in our community."