The first QantasLink flight to Orange will start on Monday.
It will bring direct competition on the Sydney-Orange route with Regional Express which has been flying the route alone for several years.
Orange mayor Reg Kidd said the airport was gearing up to accommodate increased visitor numbers.
He said it would bring an economic boost to Orange.
"Orange is a thriving regional hub and the airport is an important gateway for business and recreational travellers," he said.
Qantas will have its own check-in desk inside the airport terminal. Qantas operations staff have been setting up computer systems and equipment at the terminal this week.
COVID-19 arrangements are in place inside the terminal including hand sanitiser stations, 1.5- metre social distancing markers on the floor and sneeze shields on the service desks.
Deputy Mayor and Orange Airport Community Committee chair Cr Sam Romano said improvements at the airport included expanding the car park and installing better lighting, while further works were about to get underway as part of a $2 million upgrade.
"The car park has been extended on the eastern side and construction is set to begin on another secure 56-space covered car park designed for travellers who are away for several days," he said.
"The roof of the car park will be a huge solar panel array, which will provide additional power to the airport."
The installation of a large awning over the terminal's departure and arrival doors will provide better weather protection for passengers.
Features inside the terminal will offer better technology for business travellers including Wi-Fi, charging points, a large digital display screen and improved lounges.
DO YOU WANT MORE ORANGE NEWS?
- Receive our free newsletters delivered to your inbox, as well as breaking news alerts. Sign up below ...