Residents are invited to don the pink and green and Walk 4 Hope this Saturday.
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Huntington's NSW ACT will host its annual awareness walk through the Orange streets.
Registration for Walk 4 Hope is at 10am at Robertson Park, with the march to begin at 11am.
There will be a sausage sizzle and coffee available in the park afterwards.
Taking place on Father's Day, Walk 4 Hope aims to raise funds for the rare degenerative disease, Huntington's.
Huntington's disease is an inherited disease that causes the progressive breakdown of nerve cells in the brain.
Each year, Orange residents walk the streets in a sea of green and pink shirts before gathering in the park to hear from those who have been effected by the disease.
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