Local flora and fauna including a Spotted Pardalote bird, Diuris orchids, Mycena, Cage Fungus, Common Blue Banded bees and Neon Cuckoo bees feature in her 9.5 metre by 4.5 metre work.

The award-winning Sydney artist started painting her mural on the wall at 213 Anson Street this week as part of Orange City Council's FutureCity Art Project.

The design of the mural took months to plan and research, and was created in consultation with Dr Jordan Bailey and the team at the Department of Primary Industries (DPI), and Jenny Medd and Helmut Berndt from the Orange Field Naturalist and Conservation Society.

Fungi are at the heart of her work, she says.

"It's like the centre. It starts with them and everything grows out of it. It's like without the fungi there's not going to be any life."

Ms Tosca, who usually paints and draws on a much smaller scale, says she is "absolutely loving" working on a large public mural.

"I love being outdoors, and also making something that lots of people can see," she said.

Orange Regional Gallery director Bradley Hammond said Ms Tosca's piece was developed in response to the precarious balance of species in the Orange region.

"Biome encourages us to bear witness to the increasing number of endangered species and reminds us of the complex and delicate relationship we have with our environment."

Ms Tosca joins artists Yanni Pounartzis of Canberra, Catherine O'Donnell of the Blue Mountains, and Sandon Gibbs-O'Neill and Tully Moore of Orange in contributing to the FutureCity Public Art Project so far.

The three-year project aims to develop a diverse collection of murals and art installations on buildings in the inner city, designed to encourage foot traffic in the city centre as part of Councils' FutureCity plan to revitalise the CBD.

Orange Mayor Reg Kidd said it was exciting to see new artworks popping up all over the central business district.

"It's wonderful to see people talking about the art and sharing their opinions," Cr Kidd said.

"That's the great thing about public art, it creates conversation and points of interest for visitors and residents to explore, encouraging them to spend time in our city centre and support the local economy."

Our journalists work hard to provide local, up-to-date news to the community. This is how you can continue to access our trusted content: