At the Wednesday health briefing, Premier Gladys Berejiklian said there were 110 new locally acquired cases of COVID-10 in the 24 hours to 8pm on Tuesday, with 43 in the community while infectious.

Ms Berejiklian said nearly 84,000 people were tested on Tuesday - the highest number of tests to date.

"This is a great result, and one we need to keep up in the next few weeks," she said. "It means we are scooping up all the cases we can find.

"Had we not gone into the lockdown a couple of weeks ago, that number would undoubtedly been thousands and thousands. We have done well.

"Our vaccination rates are so low and yet we have done so well in stemming the virus. Now we need to quash it."

The higher number of tests had helped to identity the "high number" of cases in the 24 hours to 8pm on Tuesday.

NSW Health's Dr Jeremy McAnulty said there were 106 COVID-19 patients in hospital, 23 in intensive care, and 11 requiring ventilation.

"We are now seeing cases in Western Sydney increased," he said.

Mr Barilaro spoke of the lockdown in the Central West.

"As we all know, overnight on the advice of NSW Health, the NSW Government made the decision for the first time to act fast, hard and local and lock down three local government areas.

"As of today have we had a number of stay at home orders. They are you can't leave home unless for work or education, for medical or care, of course for shopping or for good and services and for exercise."

He added that he accepted that hospitality would now close unless they offer takeaway.

"These decisions were made to make sure we protect those communities," he said.

"The Central West is an intertwined region and especially areas of Molong, Blayney and Orange. The decision was the right decision to make sure we don't overwhelm the health system and on the back of the health advice.

"This is a reminder to everybody, that we in regional and rural NSW aren't somehow not going to be impacted by the Delta strain. We know it's infectious and we know it's infectious and know it's transmissible. This was a decision made on behalf of the regions."

As of midday Wednesday, there were no additional venues of concern listed on the NSW Health website.

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