A NSW Ambulance spokesman said four crews went to the scene near Summer Hill Lane, between Orange and Lucknow, about 11.50am.

He said three adults were taken to Orange Hospital while two children were treated at the scene for minor injuries.

The spokesman said a man, 45, suffered chest injuries and leg pain and was in a stable condition.

He said a woman, 40, suffered abdominal injuries while another woman, 29, suffered minor injuries.

Central West Police District Acting Inspector Luke Cole said police, ambulance and fire brigade crews responded to what was initially described as a "persons trapped accident."

Acting Inspector Cole said the highway was not closed due to the accident as the cars were off the road.