Emergency services were called vehicle left the road, rolled and hit a tree on Thursday afternoon after 3.30pm near Shadforth.

Three people were taken to hospital, including a boy with a serious head injury.

A 50-year-old woman had head lacerations and a 20-year-old woman with a leg injury.

The boy's age is unknown.

A NSW Ambulance spokesperson confirmed only one vehicle was involved in the crash.

The single-vehicle accident happened 17kms east of Orange near the intersection with Pretty Plains Road.

Four ambulance crews were on scene along with police, Rural Fire Service and State Emergency Service.

The road was shut for a period of time, with the incident believed to have occurred just after 3.30pm, with traffic diverted along Pretty Plains Road.

Several people are believed to have been taken to hospital by ambulance.

Emergency services are still on scene.