The two cars collided outside of Orange towards Lucknow near the Northern Distributor Road about 12.42pm.

Both female drivers and the female passenger were taken by NSW Ambulance to Orange hospital with non-life-threatening injuries.

NSW Fire and Rescue Orange station officer Shane Brinkworth said the road was closed in both directions and firefighters cut away the side of one vehicle so the female driver could be removed.

"We had an off-duty Fire and Rescue firefighter who witnessed the accident and was able to render first aid," Mr Brinkworth said.

The woman's pregnant passenger was not trapped in the car and the female driver of the other vehicle was also not trapped and all three were taken by ambulance to Orange hospital.

Police, ambulance, Lucknow Rural Fire Service and NSW Fire and Rescue attended the crash.

Mr Brinkworth said the firefighters were at the scene for about an hour and tow trucks were called to remove the cars from the scene.

The crash followed another collision in Orange on Saturday that caused an oil spill.

Mr Brinkworth said no one was injured in the other crash at the intersection of Peisley Street and Franklin Road.

One car from that crash had to be towed from the scene and NSW Fire and Rescue cleaned up spilled oil and petrol to prevent another crash.