Kinross Wolaroi School's 1100 students and about 330 staff are being sent home for weeks to avoid the risk of the coronavirus spreading.
Students will begin remote learning next week from their homes.
The situation will last at least until late April when the school was due to return after the Easter holiday break.
Kinross Wolaroi head of marketing and communications Jennifer Divall said the school's boarders would be collected by parents on Wednesday.
Ms Divall said the HSC students would begin remote learning next Monday with the rest of the school expected to start next Wednesday.
We haven't had to do this before. It is breaking new ground for us.Jennifer Divall, Kinross Wolaroi School
She said staff would stay at school this week to finalise the learning programs before working from home from next week.
"We haven't had to do this before. It is breaking new ground for us," she said.
Ms Divall said while some farming families would benefit from having their children back to help work the farm it was recognised working parents of city children might be inconvenienced.
"We flagged with parents to think about the [possibility] that this was going to happen," she said.
Ms Divall said students would be set work tasks rather than having regular classes conducted online.
"Teachers will be available at the normal class times to help out," she said.
She said the school was also aware regional areas might not have strong internet connections and had designed the learning programs accordingly.
Ms Divall said with the ongoing coronavirus situation it was unclear when the normal school programs could resume after the April holidays.
"We are monitoring the situation daily," she said.
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