The Regional Senior Travel Card comes pre-loaded with $250 for eligible seniors to use on taxis, fuel, Opal cards and pre-booked NSW TrainLink regional train and bus services.

Minister for regional transport Paul Toole said the card will help ease the cost of travel for eligible regional seniors.

"For aged pensioners who live in regional areas, this travel card could be the difference between making or missing a medical appointment," Mr Toole said.

"This is the first time such a scheme has been rolled out in NSW, and it was one of the Coalition government's key commitments at the 2019 state election."

The scheme is eligible to seniors with a valid Pensioner Concession Card or a Commonwealth Seniors Health Card issued by either the Department of Human Services or Department of Veterans' Affairs.

Eligible seniors must live outside of the greater Sydney, Newcastle and Woolongong areas, and will have a minimum of 12 months to use their card from the time of activation.

"The scheme allows pensioners to stay connected with friends and family without the burden of significant transport costs," Mr Toole said.

"Service NSW received over 100 applications for the scheme within the first half hour of opening, which highlights the strong demand for affordable transport in regional areas."

The scheme was recently piloted recently over three weeks at Coffs Harbour.

"Following this trial, the card will be posted to seniors, with a PIN to follow a few days later with an explanation on how to activate the card," Mr Toole said.

To be eligible to receive the $250 Regional Seniors Travel Card you must be an age pensioner with a valid Pensioner Concession Card or hold a Commonwealth Seniors Health Card issued by either the Department of Human Services or Department of Veterans' Affairs.

Eligible seniors can apply through service.nsw.gov.au, by calling 137788 or visiting a Service NSW centre.