The Audi Centre Orange and the Canobolas Holden sales department have both relocated to the expanded Orange Motor Group site on Bathurst Road at the edge of town.

The Holden service department is remaining at the site in Endsleigh Avenue.

It follows the closure of the Five Ways church and the former WIN TV building plus the move by the Central West RAM dealership from the area in the past two years around the intersection.

The Department of Primary Industries is due to leave its site on Kite Street in the next nine months while a sewing shop on William and Summer streets is also moving.

Cr Kevin Duffy said while Orange's CBD was improving with the opening of the new Orange City Centre shops in the Dalton Brothers building, other areas of Orange, including Five Ways, might struggle.

"The whole thing has the potential to be the new Kurim shops like the old hospital," he said.

"This is going to be a new target."

Cr Duffy made similar remarks 14 months ago but said he was still concerned for the area.

He said he was also concerned other businesses might leave the area.

"We lost WIN TV. All that's left is Hungry Jacks. It's not an easy place to get in and out of," he said.

The DPI site will see staff move to new premises on the former Orange Base Hospital site in Prince Street next year.

Cr Duffy said he had been in contact with the building's owner.

However, Orange Business Chamber president Ash Brown said the area was well-sited near the CBD and would be in demand for a number of potential businesses.

"There are so many great businesses in that area," he said.

"There are plenty of businesses in William and McLachlan streets and further down Bathurst Road.

"Someone will come along and see an opportunity to take up that business.

"Surely there is another car dealer or similar there who can see the potential."

Mr Brown said he believed the DPI building would suit another government department decentralising or it could become high-end apartment accommodation.

"The government have looked for ways to decentralise in Orange because it works for them," he said.

Mr Brown said there was increasing demand from baby boomers to downsize to apartments that had low maintenance and little or no yards to look after.

He said there was also increasing demand for serviced apartments for tourists and for staff needed for the expansion of the Cadia mine.

"We seem to be bursting at the seams for places to stay," he said.

The former Five Ways Uniting Church was sold earlier this year.