Emergency services scrambled to the accident scene at Mount Lambie, near the intersection of Thorpes Pinch Road, at 7.13pm on Wednesday.

A Chifley Local Area Command spokeswoman said a Mazda 3 sedan travelling in easterly direction collided head-on with a large truck.

The accident left debris scattered across the roadway and the highway closed for hours.

The woman, who was the only occupant of the car, died at the scene.

Police have still not released the woman’s name.

The male truck driver was taken to Bathurst Hospital for mandatory blood and urine tests. He suffered minor injuries.

“Crime scene officers from Western Sydney were called to the scene and undertook an extensive investigation of the scene,” the police spokeswoman said.

This latest death adds to the 27 other people who have been killed on roads around Bathurst since 2012, data from Transport for NSW shows.

Along with the fatalities, 184 people were left seriously injured on Bathurst region roads.

Numbers across the Central West were just as shocking – with 161 people killed and a further 1396 seriously injured on the roads.

The investigation followed another incident 20 kilometres from Grenfell, leaving a 22-year-old South Australian man in critical condition.

Initial investigations suggest the driver of the Mazda 3 may have fallen asleep at the wheel sometime between 2am and 3am on Thursday morning after purchasing the vehicle in Sydney.

The man suffered fractures to his right femur, right arm, suspected pelvic fractures and serious head and internal injuries.

It appears the man was travelling back to South Australia in his newly acquired vehicle before crossing to the incorrect side of the road, colliding with a small tree, then a large tree.

Grenfell Police have reminded drivers of the danger of fatigue, saying it was as dangerous as drink-driving.

Anyone with information is urged to contact police.